Renal post-mortem findings in myeloproliferative and myelodysplastic/myeloproliferative neoplasms

Renal biopsy cases in myeloproliferative neoplasms (MPN)

We performed renal biopsy in three cases complicated by myeloproliferative neoplasms (MPN). Although several cases of glomerulonephritis associated with MPN have been reported, the etiologies of the renal disorders were not established (Plomley et al., Aust NZ J Med, 13:125-129, 1983; Sharma et al., Nephron, 69:361, 1995; Kanauchi et al., Intern Med, 33:36-40, 1994; Kasuno et al., Nephrol Dial ...

Tesio catheters: findings in post-mortem examination.

Vascular access is still the 'Achilles heel' in the haemodialysis treatment. Access-related problems account for approximately 25% of hospitalizations in haemodialysis patients. In patients lacking a suitable vascular anatomy or presenting repeated a-v fistula thrombosis due to vascular problems and/or hypotension, a permanent central venous catheter can establish a reliable long-term vascular ...

Myeloproliferative neoplasms and thrombosis.

Major causes of morbidity and mortality in myeloproliferative neoplasms are represented by arterial and venous complications, progression to myelofibrosis, and transformation to acute leukemia. The pathogenesis of thrombosis results from a complex interplay of clinical and disease-related factors. Abnormalities of blood cells arising from the clonal proliferation of hematopoietic stem cells inv...

Epigenetics in Myeloproliferative Neoplasms

A decade on from the description of JAK2 V617F, the MPNs are circumscribed by an increasingly intricate landscape. There is now evidence that they are likely the result of combined genetic dysregulation, with several mutated genes involved in the regulation of epigenetic mechanisms. Epigenetic changes are not due to a change in the DNA sequence but are reversible modifications that dictate the ...

Renal papillary necrosis: retrospective post-mortem study.